Ulempene ved farmakologiske intervensjoner er mangelen på ekte ”tilpasning” eller forandring av atferd, tanker og følelser. Dessuten kan den såkalte statistiske filtreringen av pasientpopulasjonen ha en negativ effekt. Statistisk filtrering betyr at guy gir et stort antall pasienter en bestemt medisin (kanskje for mye), og at de som ikke hje
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